Maghnite-H+ Clay as Acid Eco-Friendly Catalyst for the Synthesis of Pyrimidinone Derivatives

Abstract

A useful and efficient procedure was obtained for the synthesis of pyrimidinone derivatives 3a-f via reaction of 2-aminobenzimidazole 1a-b and β-cetoesters in the presence of proton exchanged algerian montmorillonite clay (MMT-H+) as green catalyst with high yields. The main advantages of using this protonated solid non-toxic catalyst in this synthesis are its availability and low cost, the simplicity of its use, the recycling possibilities without significant loss of its catalytic activity and its environmentally benign process.