The Effect of Calcium Intake on Faecal Calcium and its Relation to Spasticity in The Spastic Rats Model

Abstract

The most important element in food in the formation of teeth, bones and soft tissues and plays a role in various metabolic processes in the body is calcium. Hypocalcemia causes hyperexcitability of the nervous system which can induce spasticity due to deficiency of calcium intake or impaired absorption of calcium due to hypoparathyroidism or due to excessive loss of calcium through the kidneys. High phosphate intake can also increase calcium in the intestine. If the absorption of calcium in the intestine decreases, there will be an increase in calcium excretion through the faecal. The theory about the role of calcium in muscle contraction and its excretion through faecal needs to be investigated to determine the effect of calcium intake on faecal calcium in relation to spasticity in spastic rat models. The main materials used in this study were calcium lactate powder and aquadest. A total of 42 experimental animals were male Sprague Dawley rats aged 10-12 weeks weighing 200-250 g. Rats were obtained from Biofarmaka IPB and received a laboratory animal health certificate. Stool samples were taken as much as 2 g before and after the intervention. Calcium mineral solution was measured by the intervention AAS method carried out for 15 days. in groups K5 and K6 who received calcium intake of 400 mg and 500 mg experienced a decrease in faecal calcium levels. Increased calcium intake causes increased absorption of calcium in the intestine and reduced excretion of calcium with faecal, associated with increased levels of calcium in the blood.